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Insertion of GCase Trp side chains into the membrane. A, top, GCase ...
Gaucher mutations of GCase mapped onto the three-dimensional structure ...
Structure of GCase at the membrane interface revealed by neutron ...
GCase Enhancers: A Potential Therapeutic Option for Gaucher Disease and ...
Structure of WT GCase highlighting the potential ldLIMP2 binding ...
Active sites from different GCase structures. (a) Superposition of ...
Secreted human GCase from hGBA1-NPCs restored GCase deficiency in mouse ...
Mutant GCase undergoes ubiquitination and associates with parkin. (A ...
In vivo ␣ -syn-GCase interaction. A , immunoprecipitation of GCase with ...
In situ assay for GCase activity reveals inhibition of lysosomal GCase ...
Enhancement of both GCase activity and protein levels in an enriched ...
5 GCase activity increase in WT GBA1 AV transduced cells Neurons ...
PGRN is required for lysosomal appearance of GCase. (a) GCase enzymatic ...
Interaction of GCase and deuterated -syn on the membrane probed by ...
Mature WT GCase amino acid sequence highlighting the regions targeted ...
Effect of lactacystin on the expression of GCase and net enzymatic ...
Frontiers | Live cell in situ lysosomal GCase activity correlates to ...
GCase is targeted to mitochondria A Isolated mitochondria from the ...
GCase expression levels in the locus ceruleus. Green channel shows the ...
GCase RNA activity and protein levels in cultured mouse hepatocytes and ...
The life cycle of GCase in and beyond the lysosome. AMRF: Action ...
GCase substrate levels are altered in the brain and liver of homozygous ...
Schematic representation of constructs used for targeting GCase to ...
| GCase exists in lysosomes and in mitochondria and plays a significant ...
GCase from birth to death. (a) Chromosome locus of GBA gene with 14 ...
Immunogold EM localization of GCase in transgenic Arabidopsis seeds ...
A) A structure of GCase (PDB 1OGS) showing mutation sites linked to PD ...
Reported significant changes in the levels of GCase protein, GCase ...
GCase protein levels and activity are reduced in sporadic AD brain ...
GCase activity is reduced in DA neurons with LRRK2 mutations Live-cell ...
Plot of GCase activity against GlcCer levels for control, PD 1 GBA, and ...
GCase modulates mitochondrial CI integrity and activity in iPSC-derived ...
Structure and mutagenesis of the G domain a, The overall structure of ...
GCase protein levels and activity are increased in the Abca12 ...
GCase activity and protein in C−/− mice. (A) GCase activity levels were ...
Lower Levels of Mature GCase Protein and Accumulation of Incompletely ...
GCase protein levels and activity in fibroblasts. Measurements were ...
(a) GCase double-displacement mechanism acting on its natural substrate ...
GCase activity and substrate accumulation in mutant flies. (A) A TLC ...
Live-cell GCase activity and saposin C levels are reduced in Parkin ...
A The main structural regions in depicted on 3D structure of G domain ...
GCase expression in control and GD osteoblasts and phenotypic rescue by ...
GCase is imported into mitochondria by the mitochondrial protein import ...
Quanti fi cation of GCase expression levels and measurement of enzyme ...
Correcting GBA deficits to equilibrium restores physiologic GCase and ...
GCase activity and protein in 4L;C* mice. (A) The activities of GCase ...
GCase structure and dynamics during the performed MD simulations. In ...
5 Overview of the PS use case and domain model generation | Download ...
Model structures of the membrane-bound -synGCase complex . GCase is ...
GCase expression in hGBA-NPC-treated 9H/PS-NA mouse brains (A) Human ...
Allosteric Modulation of GCase Enhances Lysosomal Activity and Reduces ...
Experimental design for in vivo efficacy study, GCase activity in mouse ...
GCase and HexA activity in autopsy brain tissue. A) GCase activity was ...
Measuring GCase activity by flow cytometry. (a) Peripheral blood ...
Bound phenols in GCase (Structure B) (A) Overall view of modeled ...
Loss of GCase activity disrupts mitochondria–lysosome contact ...
GT-02287, a clinical stage GCase enhancer
Spatial variation of the test case domain after 2 × 10 6 seconds for ...
Simple case domain with boundary conditions. | Download Scientific Diagram
LysoFQ-GBA reports on lysosomal GCase activity in different lineages of ...
Potential mechanisms linking mutant GCase with PD. Loss of enzymatic ...
Use case: Domain Expert | Download Scientific Diagram
Compositions and methods for treatment of gcase related disease states ...
Evaluation of GCase and related genes (A, C) Western blot showing ...
Test-case domain and relative patches | Download Scientific Diagram
Effect of treatments on GCase activity in GBAKO-THP1 monocytes ...
GCase
2D IBVP test case: domain and boundary specifics (upper left ...
(PDF) Live cell in situ lysosomal GCase activity correlates to alpha ...
GCase activity and protein levels in mononuclear cells from control and ...
Schematic diagram showing a possible biological role for ␣ -syn in the ...
The structure of the GBA1 gene and the encoded GBA1 protein ...
Superposition of GH30 family member structures. Cartoon representation ...
The predicted GCase-SAPC interface. (A) Residues in red are those ...
Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase ...
GCase-GFP transfection constructs for Gba1 null/null cells. On the left ...
LIMP-2-mediated interactions. (a) SPR experiment showing that β-GCase ...
GCase-BS lysosomal mode of action in vitro a Immunolabeling of hBS and ...
Schematic illustration of the designed approach for β-GCase activity ...
GBA1 - Target in Neurodegenerative Diseases
Syn-GCase interaction model. View of loop 1 (residues 311– 319) and ...
GCase-BS proof of concept in vivo. | Download Scientific Diagram
Molecular imaging of membrane interfaces reveals mode of β-glucosidase ...
GCase, HEX and β-gal enzymatic activities stabilized from 0 to 6 days ...
Relationship between glucocerebrosidase (GCase) and neurologic diseases ...
Schematic depiction of GBA1 targeting strategy. The GBA1 D409V KI ...
SPR experiments for the interaction of LIMP-2 with CI-MPR and ...
GCase-BS lysosomal mode of action in vitro. | Download Scientific Diagram
Possible mechanisms underlying the link between GCase, alpha-synuclein ...
Abbreviations GD: Gaucher disease; GCase: Acid β-glucosidase; GlcCer ...
HT OMASE environment view for the use case-domain model for steam ...
Glucosylceramidase (GCase) enzyme stability in human leukocyte ...
PPT - Structure, function and mechanisms of G-Proteins PowerPoint ...
Interaction surfaces for GCase-SapC complex identified by computational ...
Parkinson’s Disease Resource Center | Cell Signaling Technology
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional ...
A small subgraph of the case-domain graph. | Download Scientific Diagram
Glycomimetic-based pharmacological chaperones for lysosomal storage ...
Our Science - Congruence
Rehabilitating Mutant GCase: Chemistry & Biology
Alignment of WT and dGCase3 structures. (A, B) Crystal structure of WT ...
